H-2Kb-tsA58转基因小鼠海马神经上皮细胞的免疫特性分析
Immunocharacterization of H-2Kb-tsA58 transgenic mouse hippocampal neuroepithelial cells.
作者信息
Kershaw T R, Rashid-Doubell F, Sinden J D
机构信息
Neurodegenerative Diseases Research Group, Institute of Psychiatry, De Crespigny Park, London, UK.
出版信息
Neuroreport. 1994 Oct 27;5(16):2197-200. doi: 10.1097/00001756-199410270-00052.
Abstract
From dissected fragments of embryonic H-2Kb-tsA58 transgenic mouse hippocampal neuroepithelium, we have derived a population of rapidly proliferating, nestin-positive conditionally immortal hippocampal neuroepithelial cells. Treatment with dibutyryl cAMP in non-permissive culture conditions resulted in cessation of cell division and differentiation of the precursor cells into neuronal or glial phenotypes.
摘要
从胚胎期H-2Kb-tsA58转基因小鼠海马神经上皮的解剖碎片中，我们获得了一群快速增殖、巢蛋白阳性的条件性永生化海马神经上皮细胞。在非允许培养条件下用二丁酰环磷腺苷处理导致细胞分裂停止，前体细胞分化为神经元或神经胶质表型。
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