难治性疾病与骨髓移植

Intractable diseases and bone marrow transplantation.

作者信息

Ikehara S

机构信息

First Department of Pathology, Kansai Medical University, Osaka, Japan.

出版信息

Pathol Int. 1994 Dec;44(12):817-26. doi: 10.1111/j.1440-1827.1994.tb01678.x.

DOI:10.1111/j.1440-1827.1994.tb01678.x

PMID:7866564

Abstract

Intractable diseases are defined as diseases of unknown etiopathogenesis, and for which therapeutic strategies remain to be established. They are therefore likely to cause various sequelae. Of the 86 intractable diseases recognized by the Ministry of Health and Welfare of Japan, half are thought to be curable by bone marrow transplantation (BMT). This report shows which diseases are curable by BMT and provides evidence that autoimmune diseases are stem cell disorders.

摘要

疑难病症被定义为病因发病机制不明且治疗策略仍有待确立的疾病。因此，它们很可能引发各种后遗症。在日本厚生省认定的86种疑难病症中，有一半被认为可通过骨髓移植（BMT）治愈。本报告指出了哪些疾病可通过BMT治愈，并提供证据表明自身免疫性疾病是干细胞紊乱性疾病。