新型食欲抑制剂AN 448的双盲交叉研究
Double blind cross-over study of a new appetite suppressant AN 448.
作者信息
Haugen H N
出版信息
Eur J Clin Pharmacol. 1975;8(1):71-4. doi: 10.1007/BF00616417.
PMID:786676
Abstract
The effects of a new appetite suppressant, AN 448, and a placebo have been compared in 30 obese individuals using a fully randomized double-blind cross-over design. 1 mg of AN 448 t.i.d. produced a significant degree of appetite suppression and a mean weight loss of more than 4 kg per individual over a 6 week period. Side effects were few and no haematological, renal or hepatic damage was observed.
摘要
采用完全随机双盲交叉设计，在30名肥胖个体中比较了一种新型食欲抑制剂AN 448和安慰剂的效果。每天三次，每次1毫克的AN 448产生了显著程度的食欲抑制，并且在6周的时间里，每个个体平均体重减轻超过4千克。副作用很少，未观察到血液学、肾脏或肝脏损伤。
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