Baird I M, Howard A N
Int J Obes. 1977;1(3):271-8.
Thirty-eight obese patients, resistant to conventional diet therapy, agreed to consume a 1.09 MJ (260 kcal)/day semi-synthetic diet consisting of 25 g egg albumin, 40 g oligosaccharides, vitamins and minerals, and were seen weekly as outpatients for eight weeks. At the beginning, the semi-synthetic diet was given with either the anorectic drug, mazindol (2 mg/day) or a placebo for four weeks and then changed over for the remaining four weeks; the study being conducted on a double-blind basis. The final treatment was a 4.2 MJ (1000 KCAL) conventional diet for a further four weeks without drug or placebo. Twenty-five patients completed the first eight weeks and 21 patients the final four weeks of the trial. The total mean weight losses were as follows: week 4, 9.3 kg; week 8, 13.7 kg; week 12, 12.2 kg. There was no significant difference in weight loss between mazindol treatment and placebo but the former group reported feeling less hungry. The chief side-effects observed were dizziness, nausea, dry mouth, insomnia and depression which were more frequent with mazindol. Six patients had to stop mazindol because of side-effects, but were able to continue the diet alone. It is concluded that a semi-synthetic diet containing 1.09 MJ (260 kcal) daily can be successfully employed in the treatment of obese outpatients, and is a practical therapeutic alternative to admission to hospital. There is no clinical advantage to be gained by the additional use of the anorectic drug, mazindol.
38名对传统饮食疗法有抵抗性的肥胖患者同意食用一种每天1.09兆焦耳（260千卡）的半合成饮食，该饮食由25克蛋清、40克低聚糖、维生素和矿物质组成，并且作为门诊病人每周接受观察，为期8周。开始时，半合成饮食与食欲抑制剂马吲哚（2毫克/天）或安慰剂搭配服用4周，然后在接下来的4周进行更换；该研究采用双盲方式进行。最后4周的治疗是一种4.2兆焦耳（1000千卡）的传统饮食，不服用药物或安慰剂。25名患者完成了试验的前8周，21名患者完成了试验的最后4周。总体平均体重减轻情况如下：第4周，9.3千克；第8周，13.7千克；第12周，12.2千克。马吲哚治疗组和安慰剂组在体重减轻方面没有显著差异，但前一组报告饥饿感较轻。观察到的主要副作用是头晕、恶心、口干、失眠和抑郁，这些在马吲哚组中更常见。6名患者因副作用不得不停止服用马吲哚，但能够继续单独饮食。结论是，一种每天含有1.09兆焦耳（260千卡）的半合成饮食可成功用于治疗肥胖门诊病人，是一种切实可行的替代住院治疗的方法。额外使用食欲抑制剂马吲哚没有临床益处。
