Sheng Y, Zheng Q, Guo F, Liu B, Zhang J, Li Y
Department of Pathology, Ningxia Medical College, Yinchuan.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(3):178-81.
Pathological changes in alveolar hydatids from experimentally infected gerbils were studied after administration of albendazole or praziquantel. The animals were divided into several groups including the control one, and drugs of different dosages were given separately to different groups with diverse durations of infection. According to the microscopical observation, the hydatids could be categorized into 3 grades: grade I, degenerated cysts; grade II, stable cysts (showing no proliferation); grade III, proliferated cysts. Larger proportion of grade I cysts were found in the group treated with albendazole at high dosage (33.3%) and the two groups treated with praziquantel (25.0% and 16.3%). The proportion of grade I cysts in gerbils with shorter duration (45 d) of infection was larger than those with longer duration (60 d). Lymphocyte infiltration to various extent was present surrounding the alveolar hydatid cysts in all the treated groups. More marked infiltration of lymphocytes was observed in albendazole treated gerbils (106.9 +/- 34.3-300.1 +/- 59.5) (P < 0.001). However, the combined medication of albendazole and praziquantel was less efficacious.
在给实验性感染的沙鼠施用阿苯达唑或吡喹酮后，研究了肺泡包虫的病理变化。将动物分为包括对照组在内的几个组，将不同剂量的药物分别给予不同组，感染持续时间各不相同。根据显微镜观察，包虫可分为3级：I级，退化囊肿；II级，稳定囊肿（无增殖）；III级，增殖囊肿。在高剂量阿苯达唑治疗组（33.3%）和吡喹酮治疗的两组（25.0%和16.3%）中发现I级囊肿的比例较大。感染持续时间较短（45天）的沙鼠中I级囊肿的比例高于感染持续时间较长（60天）的沙鼠。在所有治疗组中，肺泡包虫囊肿周围均有不同程度的淋巴细胞浸润。在阿苯达唑治疗的沙鼠中观察到更明显的淋巴细胞浸润（106.9±34.3 - 300.1±59.5）（P<0.001）。然而，阿苯达唑和吡喹酮联合用药的效果较差。
