Wei G Z, Zhang J, Sheng S L
Beijing Xuanwu Hospital.
Zhonghua Nei Ke Za Zhi. 1994 Jun;33(6):388-90.
In acute cerebral ischemia there are severe damages of endothelium recognized as the stimuli for secretion of endothelin-1, that is a endothelium-derived peptide and seems to be the most potent vasoconstrictor known. The goal of this study is to measure plasma endothelin-1 level in patients with cerebral infarction and determine the relationship between endothelin-1 and ischemic stroke. Plasma level of endothelin-1 was measured in 21 consecutive patients. The measurement was performed 3 times at different stages of stroke. There was a marked increase in plasma endothelin-1 level in the patients and the elevation lasted the entire acute and subacute stage of stroke. There was a correlation between the peptide concentration and infarct volume (r = 0.665, P < 0.01). The result suggests that endothelin-1 plays an important role in the regulation of brain circulation. Apparent and lasting increase in plasma level of endothelin-1 is associated with cerebral ischemia and infarction. The peptide seems to be involved in the pathophysiology of acute cerebral ischemia and have a deleterious effect in the evolution of cerebral infarction.
在急性脑缺血中，内皮细胞会受到严重损伤，这被认为是内皮素-1分泌的刺激因素。内皮素-1是一种内皮源性肽，似乎是已知最强效的血管收缩剂。本研究的目的是测量脑梗死患者血浆内皮素-1水平，并确定内皮素-1与缺血性中风之间的关系。对21例连续患者测量了血浆内皮素-1水平。在中风的不同阶段进行了3次测量。患者血浆内皮素-1水平显著升高，且在中风的整个急性期和亚急性期持续升高。该肽浓度与梗死体积之间存在相关性（r = 0.665，P < 0.01）。结果表明，内皮素-1在脑循环调节中起重要作用。血浆内皮素-1水平明显且持续升高与脑缺血和梗死有关。该肽似乎参与了急性脑缺血的病理生理学过程，并在脑梗死的发展中具有有害作用。
