Elshazly M A, Serwadda D M, Freers J
Department of Medicine, Mulago Hospital, Makerere University, Uganda.
East Afr Med J. 1994 Aug;71(8):496-500.
This study was carried out to investigate the endoscopic and histopathological findings in AIDS patients in Mulago Hospital, in Uganda who present with upper gastrointestinal symptoms. Any observed morphological changes were biopsied. Duodenal contents were aspirated in each case for microscopic examination. Vomiting was reported in 100% of the patients, dysphagia and epigastric pain were reported in 89%. Other symptoms reported in decreasing frequency were odynophagia 46%, retrosternal chest pain 40%, haematemesis 10%, and hiccough 3%. Up to 74% of the patients had morphological changes in the oesophagus, while 28% showed changes in the stomach. Only 15% demonstrated changes in the duodenum. Duodenal aspirate revealed giardia lamblia 22%, Acid fast bacilli 7% and cryptosporidium 5%. Endoscopic findings were mostly observed in the oesophagus. Candida was the main pathogen detected. Also atrophic gastritis is a recognizable finding in these patients.
本研究旨在调查乌干达穆拉戈医院出现上消化道症状的艾滋病患者的内镜检查和组织病理学结果。对观察到的任何形态学变化进行活检。对每个病例抽取十二指肠内容物进行显微镜检查。100%的患者报告有呕吐症状，89%的患者报告有吞咽困难和上腹部疼痛。报告频率逐渐降低的其他症状有吞咽痛46%、胸骨后胸痛40%、呕血10%和打嗝3%。高达74%的患者食管有形态学变化，而28%的患者胃有变化。只有15%的患者十二指肠有变化。十二指肠抽吸物显示兰氏贾第鞭毛虫22%、抗酸杆菌7%和隐孢子虫5%。内镜检查结果大多见于食管。念珠菌是检测到的主要病原体。此外，萎缩性胃炎在这些患者中是一个可识别的发现。
