Christie D L, Ament M E
Gastroenterology. 1976 Nov;71(5):726-8.
Intravenous metoclopramide (M) was compared to placebo (P) by a double blind crossover design to determine whether M was superior to P in difficult cases of intubation of the small intestine, using a multipurpose biopsy tube and capsule. Metoclopramide decreased intubation time in 20 volunteers successfully intubated with M and P (P less than 0.05). Of 9 subjects, 8 were intubated to ligament of Treitz with M but not with P (P less than 0.01). Of 29 volunteers, 22 were successfully intubated by 15 min when M was given, but only 9 of the 29 could be intubated in 15 min with P (P less then 0.001). Of 29 volunteers receiving M, 9 experienced side effects but none were serious. This study demonstrated that M is superior to P in decreasing intubation time of a small intestinal biopsy capsule and is particularly useful in patients who may not otherwise be sucessfully intubated.
采用双盲交叉设计，将静脉注射甲氧氯普胺（M）与安慰剂（P）进行比较，以确定在使用多用途活检管和胶囊进行小肠插管的困难病例中，M是否优于P。甲氧氯普胺缩短了20名先后接受M和P成功插管的志愿者的插管时间（P<0.05）。9名受试者中，8名使用M时插管至屈氏韧带，而使用P时则未成功（P<0.01）。29名志愿者中，给予M后22名在15分钟内成功插管，但使用P时，29名中只有9名能在15分钟内插管成功（P<0.001）。接受M的29名志愿者中，9名出现副作用，但均不严重。该研究表明，M在缩短小肠活检胶囊插管时间方面优于P，尤其适用于其他方式可能无法成功插管的患者。
