铁状态对大鼠肝脏中3-磷酸甘油醛脱氢酶表达的影响。
The effect of iron status on glyceraldehyde 3-phosphate dehydrogenase expression in rat liver.
作者信息
Quail E A, Yeoh G C
机构信息
Department of Biochemistry, University of Western Australia, Nedlands.
出版信息
FEBS Lett. 1995 Feb 13;359(2-3):126-8. doi: 10.1016/0014-5793(95)00023-3.
The influence of iron status on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats. While iron loading did not alter GAPDH expression, iron deficiency evoked a 2.3-fold increase in the steady-state level of liver GADPH mRNA, but did not affect gene transcription or intracellular localisation of the message. Therefore, the over-expression of GAPDH mRNA in iron deficiency is probably due to increased message stability.
在成年Wistar大鼠的全肝样本中，研究了铁状态对甘油醛-3-磷酸脱氢酶（GAPDH）基因转录、mRNA水平及分布的影响。铁负荷增加并未改变GAPDH的表达，而缺铁使肝脏GADPH mRNA的稳态水平升高了2.3倍，但不影响基因转录或该信息在细胞内的定位。因此，缺铁时GAPDH mRNA的过表达可能是由于信息稳定性增加所致。
Zotero 插件