Prescott R J, Banerjee S S, Eyden B P, Haboubi N Y
Department of Pathology, Bolton General Hospital, UK.
Histopathology. 1994 Nov;25(5):421-9. doi: 10.1111/j.1365-2559.1994.tb00003.x.
Four cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.
本文描述了4例皮肤上皮样血管肉瘤，并指出了将这些肿瘤误诊为低分化癌或恶性黑色素瘤的潜在诊断陷阱。使用四种内皮标志物的免疫表型分析显示，所有病例中VIII因子相关抗原均呈阳性染色，主要为核旁点状，CD31（JC70）也呈阳性染色；3例CD34（QB-END/10）呈阳性，2例UEA-1呈阳性。与非皮肤部位报道的阳性染色相反，所有4例细胞角蛋白（CAM 5.2和AE1/AE3）均为阴性。1例出现异常S-100蛋白表达。2例随后复发的肿瘤比原发肿瘤分化更好。电子显微镜检查证实不存在非内皮分化系，但未发现魏-帕小体。
