Orchard G E, Zelger B, Jones E W, Jones R R
Department of Dermatopathology, St John's Dermatology Centre, St Thomas' Hospital, London, UK.
Histopathology. 1996 Mar;28(3):235-40. doi: 10.1046/j.1365-2559.1996.d01-411.x.
Four endothelial cell markers, two selective cytokeratin markers and a monoclonal smooth muscle antibody (SMA) were employed in the assessment of 19 cases of cutaneous angiosarcoma classified according to their degree of tumour differentiation. No labelling was seen for SMA or with cytokeratin markers MNF116 and CBL170. Expression of factor VIII-related antigen was seen in two tumours and positivity for CD34 (QBend 10 antibody) was found in four tumours. By contrast the pan-endothelial cell marker Ulex europeaus agglutinin 1 (UEA-1) and the CD31 marker JC70A labelled all cases of cutaneous angiosarcoma with the exception of one poorly differentiated tumour. These data confirm the endothelial cell origin of angiosarcoma, they demonstrate that CD31 and UEA1 are reliable markers in routinely processed tissue, and they suggest a lymphatic derivation for the tumour. This finding is in marked contrast to Kaposi's sarcoma where CD34 is the most reliable marker.
使用四种内皮细胞标志物、两种选择性细胞角蛋白标志物和一种单克隆平滑肌抗体（SMA）对19例根据肿瘤分化程度分类的皮肤血管肉瘤进行评估。未观察到SMA或细胞角蛋白标志物MNF116和CBL170的标记。在两个肿瘤中观察到因子VIII相关抗原的表达，在四个肿瘤中发现CD34（QBend 10抗体）呈阳性。相比之下，泛内皮细胞标志物欧洲荆豆凝集素1（UEA-1）和CD31标志物JC70A标记了所有皮肤血管肉瘤病例，但有一个低分化肿瘤除外。这些数据证实了血管肉瘤的内皮细胞起源，表明CD31和UEA1是常规处理组织中的可靠标志物，并提示该肿瘤起源于淋巴管。这一发现与卡波西肉瘤形成鲜明对比，在卡波西肉瘤中CD34是最可靠的标志物。
