Bosshardt S C, Coleman S U, McVay C S, Jones K L, Klei T R
Centers for Disease Control, Atlanta, Georgia 30341-3724.
Infect Immun. 1995 Mar;63(3):940-5. doi: 10.1128/iai.63.3.940-945.1995.
The purpose of these experiments was to define the significance of the microfilarial stage to the hyporesponsive condition seen in lymphatic filariasis. Two types of experiments were conducted with Brugia pahangi-infected gerbils. In one, in vitro lymphocyte blastogenesis and in vivo granuloma formation in response to parasite antigen were correlated to microfilaremia in chronically infected individuals. In a second set of experiments, the level of in vivo granuloma formation was assessed following chemotherapeutic removal of microfilariae with ivermectin. The results indicated that the microfilarial stage alone is not responsible for the maintenance of the low cellular responses seen during chronic infections in this model. Furthermore, the data suggest that the degree of downregulation of these responses may be related to parasite burden.
这些实验的目的是确定微丝蚴阶段对于淋巴丝虫病中所见低反应状态的意义。对感染了彭亨布鲁线虫的沙鼠进行了两种类型的实验。在其中一项实验中，将体外淋巴细胞增殖和体内对寄生虫抗原的肉芽肿形成与慢性感染个体的微丝蚴血症相关联。在第二组实验中，在用伊维菌素进行化学疗法清除微丝蚴后，评估了体内肉芽肿形成的水平。结果表明，仅微丝蚴阶段并不负责维持该模型慢性感染期间所见的低细胞反应。此外，数据表明这些反应的下调程度可能与寄生虫负荷有关。
