Fleming C, Nice L, Hughes A O, Hull M G
University of Bristol, Department of Obstetrics and Gynaecology, St Michael's Hospital, UK.
Hum Reprod. 1994 Nov;9(11):2164-6. doi: 10.1093/oxfordjournals.humrep.a138411.
It has been suggested that seasonal variation in endometrial receptivity may occur in women, which could affect the likely success of in-vitro fertilization (IVF) treatment. We therefore studied implantation rates (fetal sacs as a proportion of embryos transferred) as an indirect index of receptivity in a narrowly defined population of women under 40 years old with normal ovulatory cycles and normal uterus and men with normal sperm function. A total of 577 cycles of IVF treatment were undertaken using a standard protocol of pituitary desensitization and ovarian stimulation during the 3 years 1990-1992. Results were compared between calendar months and 3-month seasons. The overall implantation rate was 14.9% of embryos, and the clinical pregnancy rate was 30.3% of cycles reaching egg collection. There were no significant differences in the monthly rates of eggs collected, fertilization and cleavage, or embryos transferred. Implantation rates varied to a greater extent but analysis of variance showed no seasonal variation. These findings do not support a seasonal variation in ovarian responsiveness or endometrial receptivity when stimulated for IVF treatment, but larger studies are needed for firm conclusions to be drawn.
有人提出，女性子宫内膜容受性可能存在季节性变化，这可能会影响体外受精（IVF）治疗的成功率。因此，我们在一个狭义的人群中进行研究，该人群为40岁以下排卵周期正常、子宫正常且男性精子功能正常的女性，将着床率（妊娠囊数占移植胚胎数的比例）作为容受性的间接指标。在1990年至1992年的3年期间，按照垂体脱敏和卵巢刺激的标准方案进行了总共577个IVF治疗周期。将结果在日历月和3个月的季节之间进行比较。总体着床率为胚胎数的14.9%，临床妊娠率为取卵周期数的30.3%。在每月的取卵率、受精率、卵裂率或移植胚胎数方面没有显著差异。着床率的变化幅度更大，但方差分析显示没有季节性变化。这些发现不支持在IVF治疗刺激时卵巢反应性或子宫内膜容受性存在季节性变化，但需要更大规模的研究才能得出确凿结论。
