血小板在犬内毒素休克发病机制中的作用。
Role of platelets in the pathogenesis of canine endotoxin shock.
作者信息
From A H, Fong J S, Chiu T, Good R A
出版信息
Infect Immun. 1976 Jun;13(6):1591-4. doi: 10.1128/iai.13.6.1591-1594.1976.
Endotoxin-platelet interactions are thought to be of major importance in the response of dogs and other species to bacterial endotoxin; the mechanisms postulated are: (i) the release of vasoactive substances, (ii) the formation of occlusive platelet aggregates, and (iii) induction of intravascular coagulation. The role of platelets in canine endotoxin shock was examined in animals with thrombocytopenia induced by estrogen pretreatment (less than 10,000 platelets/mm3) and in controls. After intravenously administered endotoxin, the hemodynamic responses, mortality, and gross necropsy findings were similar in both groups. These data indicate that endotoxin-platelet interactions are not determinative in the pathogenesis of canine endotoxin shock.
内毒素与血小板的相互作用被认为在犬类和其他物种对细菌内毒素的反应中起主要作用；推测的机制有：（i）血管活性物质的释放，（ii）闭塞性血小板聚集体的形成，以及（iii）血管内凝血的诱导。通过雌激素预处理诱导血小板减少（血小板计数低于10,000/mm³）的动物和对照组动物被用于研究血小板在犬类内毒素休克中的作用。静脉注射内毒素后，两组动物的血流动力学反应、死亡率和大体尸检结果相似。这些数据表明，内毒素与血小板的相互作用在犬类内毒素休克的发病机制中不起决定性作用。
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