硫酸多粘菌素B对细菌内毒素的修饰：对犬内毒素休克发展的影响
Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs.
作者信息
From A H, Fong J S, Good R A
出版信息
Infect Immun. 1979 Mar;23(3):660-4. doi: 10.1128/iai.23.3.660-664.1979.
Abstract
The effects of endotoxin (lipopolysaccharide [LPS]) on the pathogenesis of canine endotoxin shock were compared with those of LPS which had interacted with polymyxin B sulfate prior to administration. Both LPS and polymyxin B-modified LPS caused comparable early decreases in aortic blood pressure, leukocyte and platelet numbers, and serum complement levels. However, in dogs receiving polymyxin B-modified LPS the late hypotensive phase was significantly ameliorated and lethality was significantly decreased. These data indicate that polymyxin B-modified LPS, though significantly less lethal than unmodified LPS, was capable of major interactions with several components of the humoral defense system, and support the concept that such interactions are not determinative in the pathogenesis of canine endotoxin shock.
摘要
将内毒素（脂多糖[LPS]）对犬内毒素休克发病机制的影响与给药前与硫酸多粘菌素B相互作用的LPS的影响进行了比较。LPS和多粘菌素B修饰的LPS均导致主动脉血压、白细胞和血小板数量以及血清补体水平出现相当的早期下降。然而，在接受多粘菌素B修饰LPS的犬中，晚期低血压阶段得到显著改善，致死率显著降低。这些数据表明，多粘菌素B修饰的LPS虽然致死性明显低于未修饰的LPS，但能够与体液防御系统的几个成分发生主要相互作用，并支持这样一种观点，即这种相互作用在犬内毒素休克的发病机制中不起决定性作用。
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