Ishii Y, Sayama K, Ohtsuka H, Shiraishi S, Miki Y
Department of Dermatology, University of Ehime School of Medicine, Japan.
J Dermatol. 1994 Dec;21(12):974-8. doi: 10.1111/j.1346-8138.1994.tb03323.x.
A 37-year-old male presented with a cauliflower-like tumor in the right buccal mucosa, leukoplakia of the tongue and esophagus, and keratotic papules or plaques on the extremities including bilateral palms and soles, associated with borderline diabetes mellitus and a repeated history of infections. A multi-system keratinizing abnormality was suspected, although no distinct disease category has been found showing similar involvements.
