Tyldesley W R, Kempson S A
J Oral Pathol. 1975 Sep;4(2):49-58. doi: 10.1111/j.1600-0714.1975.tb01852.x.
Ultrastructural studies have been carried out on epithelium taken from the oral lesions of tylosis-related leukoplakia and preleukoplakia in a group of patients known to be at high risk for esophageal carcinoma. Several structural abnormalities are described; in particular, the presence of intranuclear electron dense particles 90 nm in diameter. Similar particles have been found in the nuclei of epithelial cells from an esophageal carcinoma developing in one of the patients under study.
对一组已知患食管癌风险较高的患者，其与掌跖角化病相关的白斑和白斑前期口腔病变的上皮组织进行了超微结构研究。描述了几种结构异常；特别是存在直径为90纳米的核内电子致密颗粒。在一名正在研究的患者所患的食管癌上皮细胞核中也发现了类似颗粒。
