Bennani S, Louahlia S, Aboutaieb R, el Mrini M, Benjelloun S
Service d'Urologie, CHU Averroès, Casablanca, Maroc.
J Urol (Paris). 1994;100(4):210-6.
The authors report two cases of carcinosarcoma of the bladder, review the literature, and study the clinical, histological, therapeutic and evolutive aspects of this unusual tumor. It is a rare tumor which represent less than 0.5 per cent of all cancers of the bladder. It is three times more frequent in men than in women. Hematuria is the most frequent alarming symptom and pathogenesis is still a matter of debate. Diagnosis is based on the pathological examination including immunohistochemical study and, if necessary, with electron microscopy examination. The tumor contains two highly malignant cellular components: one is epithelial and the other is mesenchymal. Treatment is not well codified. Early diagnosis and radical cystectomy seem to improve the prognosis, which is usually poor. 5 year survival rate is about 20 per cent.
作者报告了两例膀胱癌肉瘤病例,回顾了相关文献,并研究了这种罕见肿瘤的临床、组织学、治疗及演变方面。它是一种罕见肿瘤,占所有膀胱癌的比例不到0.5%。男性发病频率是女性的三倍。血尿是最常见的警示症状,其发病机制仍存在争议。诊断基于病理检查,包括免疫组化研究,必要时还需进行电子显微镜检查。该肿瘤包含两种高度恶性的细胞成分:一种是上皮成分,另一种是间叶成分。治疗方法尚未规范。早期诊断和根治性膀胱切除术似乎可改善预后,而其预后通常较差。5年生存率约为20%。