Holt P G, Fimmel P J, Bartholomaeus W N, Roberts L M, Tandon M K, Keast D
Int Arch Allergy Appl Immunol. 1976;51(5):560-73. doi: 10.1159/000231629.
Cellular immune responsiveness (CMI) to ubiquitous bacterial antigens was assessed in serial peripheral blood samples collected from normal subjects, employing three in vitro correlates of CMI in parallel. Delayed cutaneous hypersensitivity (DCH) was also assessed on a number of occasions in these subjects. These experiments showed that the reactivity of peripheral blood leukocytes from normal individuals as measured in each of the in vitro tests fluctuated from day to day, and that the reactivity of cells functioning in each of the tests fluctuated independently of one another. In contrast, DCH reactivity in these individuals was not subject to such fluctuations. The results are discussed in terms of the periodic appearance of functionally distinct subpopulations of T lymphocytes in the peripheral circulation.
通过同时采用三种细胞免疫反应性（CMI）的体外相关指标，对从正常受试者采集的系列外周血样本中针对普遍存在的细菌抗原的细胞免疫反应性进行了评估。还在这些受试者身上多次评估了迟发型皮肤超敏反应（DCH）。这些实验表明，在每个体外试验中所测定的正常个体外周血白细胞的反应性每日波动，并且在每个试验中发挥作用的细胞的反应性彼此独立波动。相比之下，这些个体的DCH反应性不存在此类波动。根据外周循环中功能不同的T淋巴细胞亚群的周期性出现对结果进行了讨论。
