D'Hallewin M A, Baert L, Vanherzeele H
Department of Urology at St. Pieter University Hospital, Catholic University of Leuven, Belgium.
J Am Paraplegia Soc. 1994 Oct;17(4):161-4. doi: 10.1080/01952307.1994.11735929.
The diagnosis of transitional cell bladder carcinoma and especially carcinoma in situ of the bladder in spinal cord disordered persons is often made difficult by catheters, infections or stone-induced chronic inflammation. Fluorescence tagging of tumors by sensitizing agents such as hematoporphyrin derivatives enhances visualization but presents a number of drawbacks for the patients, even at low doses. We have developed a cystoscopic fiber optic instrument, based on a mercury arc lamp, for in vivo detection of human bladder carcinoma without sensitizing agents. The tissue autofluorescence upon UV excitation (365 nm) is detected and a demarcation contrast ratio for carcinoma in situ and transitional cell carcinoma of 2.6 and 3.2 respectively is obtained. This demarcation ratio is 60 percent higher than the contrast ratio obtained after photosensitizer injection. The integration of a reliable diagnostic method with a known efficient therapeutic technique (Nd YAG laser irridiation) opens the way for cost-effective preventive care of high-risk patients.
脊髓功能障碍患者的移行细胞膀胱癌，尤其是膀胱原位癌的诊断，常常因导尿管、感染或结石引发的慢性炎症而变得困难。通过诸如血卟啉衍生物等敏化剂对肿瘤进行荧光标记可增强可视化效果，但即便使用低剂量，对患者而言仍存在诸多缺点。我们研发了一种基于汞弧灯的膀胱镜光纤仪器，用于在不使用敏化剂的情况下对人体膀胱癌进行体内检测。检测紫外线（365纳米）激发后的组织自发荧光，原位癌和移行细胞癌的分界对比度分别为2.6和3.2。该分界比比注射光敏剂后获得的对比度高出60%。将可靠的诊断方法与已知有效的治疗技术（钕钇铝石榴石激光照射）相结合，为高危患者的经济高效预防护理开辟了道路。
