Muto Y, Ichikawa H, Kitagawa O, Kumagai K, Watanabe M, Ogawa E, Seiki M, Shirataki Y, Yokoe I, Komatsu M
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Yakugaku Zasshi. 1994 Dec;114(12):980-94. doi: 10.1248/yakushi1947.114.12_980.
The antiulcer activities of 59 methanol and aqueous extracts obtained from 59 crude drugs on the ethanol-HCl-induced ulceration in rats were investigated. Among them 15 extracts were selected and they were further examined for their effects on indomethacin-, aspirin- and the water-immersion stress-induced ulcer. From these results, the methanol extract of root of Iris germanica was found to, show potent antiulcer activities. The above methanol extract was separated into 3 portions by solvent extraction, and the ether soluble portion was fractionated into 5 fractions (1 to 5) by chromatography. Fractions 4 and 5 showed significant antiulcer activities. Fraction 4 was further purified and the obtained gamma-irigermanal exhibited a potent antiulcer activity. However, further investigations are required to understand the mechanism.
研究了从59种天然药物中获得的59种甲醇提取物和水提取物对乙醇 - 盐酸诱导的大鼠溃疡的抗溃疡活性。其中15种提取物被选中，并进一步研究它们对吲哚美辛、阿司匹林和水浸应激诱导的溃疡的影响。从这些结果中发现，德国鸢尾根的甲醇提取物显示出强效的抗溃疡活性。将上述甲醇提取物通过溶剂萃取分离成3部分，醚溶性部分通过柱色谱法分成5个馏分（1至5）。馏分4和5显示出显著的抗溃疡活性。馏分4进一步纯化，得到的γ-鸢尾醛具有强效的抗溃疡活性。然而，需要进一步研究以了解其作用机制。
