Todome Y, Ohkuni H, Mizuse M, Okibayashi F, Ohtani N, Suzuki H, Song C, Igarashi H, Harada K, Sakurai S
Division of Immunology, Nippon Medical School, Kawasaki, Japan.
J Med Microbiol. 1995 Feb;42(2):91-5. doi: 10.1099/00222615-42-2-91.
Nineteen strains of Staphylococcus aureus were isolated from the throat or the tooth surfaces of 19 cases amongst 127 patients with Kawasaki syndrome (KS) during the acute phases and 11 S. aureus isolates were obtained from five of 17 diseased controls and six healthy controls. The production of exotoxins, particularly superantigenic toxic shock syndrome toxin-1 (TSST-1), coagulase serotype, pigment production, haemolytic activity and tryptophan auxotrophy of these isolates were compared. Among 10 KS S. aureus strains isolated in 1990-1991, five (50%) secreted TSST-1, a higher frequency than two (18%) of 11 control isolates. In contrast, none of the nine KS strains collected in 1984 produced TSST-1. Four of five TSST-1-secreting KS strains produced white or white to golden pigmentation, whereas the two control strains capable of TSST-1 production formed golden colonies. There were no noticeable differences between S. aureus strains from KS patients and control children in the production of staphylococcal exotoxins A-E, coagulase serotype, haemolysis of sheep erythrocytes and tryptophan auxotrophy. The pathological or aetiological role of a new TSST-1-secreting S. aureus clone in patients with KS was not confirmed.
在127例川崎病（KS）患者急性期，从19例患者的咽喉或牙齿表面分离出19株金黄色葡萄球菌，从17例患病对照和6例健康对照中的5例分离出11株金黄色葡萄球菌。对这些分离株的外毒素产生情况，尤其是超抗原性中毒性休克综合征毒素-1（TSST-1）、凝固酶血清型、色素产生、溶血活性和色氨酸营养缺陷型进行了比较。在1990 - 1991年分离的10株KS金黄色葡萄球菌菌株中，5株（50%）分泌TSST-1，这一频率高于11株对照分离株中的2株（18%）。相比之下，1984年收集的9株KS菌株均不产生TSST-1。5株分泌TSST-1的KS菌株中有4株产生白色或白色至金黄色色素，而2株能够产生TSST-1的对照菌株形成金黄色菌落。KS患者的金黄色葡萄球菌菌株与对照儿童的菌株在葡萄球菌外毒素A - E的产生、凝固酶血清型、绵羊红细胞溶血和色氨酸营养缺陷型方面没有明显差异。KS患者中一种新的分泌TSST-1的金黄色葡萄球菌克隆的病理或病因学作用尚未得到证实。
