Holm J, Nielsen N V, Hemmingsen L
Department of Clinical Chemistry Central Hospital Nykøbing Falster Nykøbing, Denmark.
Kidney Int Suppl. 1994 Nov;47:S105-8.
We performed a cross-sectional study on the urinary excretion profiles of albumin (a marker of glomerular dysfunction) and retinol-binding protein (a low molecular mass protein marker of renal proximal tubular dysfunction) in non-insulin dependent (Type II) diabetics, with or without retinopathy. The urinary excretion of both proteins, in particular retinol-binding protein, was significantly higher in patients with background/proliferative retinopathy compared to patients without retinopathy. The degree of retinopathy correlated to the urinary excretion of albumin (P < 0.005) and retinol-binding protein (P < 0.0001). Retinopathy occurred at a higher frequency in patients with above-normal urinary excretion of retinol-binding protein, both in the absence or presence of micro/macroalbuminuria. The frequency of retinopathy among micro/macroalbuminuric patients with a normal urinary excretion of retinol-binding protein did not differ significantly from that observed in patients with a normal urinary excretion of both proteins. We cannot explain the association between retinopathy and proximal tubular dysfunction in Type II diabetes. However, it is possible that both phenomena are related to a common pathogenetic factor.
我们对非胰岛素依赖型（II型）糖尿病患者（有或无视网膜病变）的白蛋白（肾小球功能障碍标志物）和视黄醇结合蛋白（肾近端小管功能障碍的低分子量蛋白质标志物）的尿排泄情况进行了一项横断面研究。与无视网膜病变的患者相比，有背景性/增殖性视网膜病变的患者中这两种蛋白质的尿排泄量，尤其是视黄醇结合蛋白，显著更高。视网膜病变的程度与白蛋白（P < 0.005）和视黄醇结合蛋白（P < 0.0001）的尿排泄量相关。在视黄醇结合蛋白尿排泄高于正常水平的患者中，无论有无微量/大量白蛋白尿，视网膜病变的发生率都更高。视黄醇结合蛋白尿排泄正常的微量/大量白蛋白尿患者中视网膜病变的发生率与两种蛋白质尿排泄均正常的患者中观察到的发生率无显著差异。我们无法解释II型糖尿病中视网膜病变与近端小管功能障碍之间的关联。然而，这两种现象有可能与一个共同的致病因素有关。
