Rowe D J, Twyman S
Department of Chemical Pathology, General Hospital, Southampton, England, United Kingdom.
Kidney Int Suppl. 1994 Nov;47:S109-10.
Although much evidence supports the theory that microalbuminuria is predictive of the development of clinical diabetic nephropathy, other experimental data fail to support this conclusion. It remains unclear whether random urine samples offer as much clinical information as timed overnight or 24 hour samples. Clinical decisions as to treatment based on improved glycemic control or enhanced antihypertensive treatment should be structured to the urinary albumin concentration. Tubular dysfunction is common in diabetes, but is clinical relevance remains unclear.
尽管有大量证据支持微量白蛋白尿可预测临床糖尿病肾病发展这一理论，但其他实验数据却未能支持这一结论。随机尿样是否能提供与定时夜间或24小时尿样同样多的临床信息仍不清楚。基于改善血糖控制或强化降压治疗的临床治疗决策应根据尿白蛋白浓度来制定。肾小管功能障碍在糖尿病中很常见，但其临床相关性仍不明确。
