Freire-Garabal M, Núñez M J, Losada C, Pereiro D, Castro-Bolaño C, Gándara J, Varela-Patiño M P, Rey-Méndez M
NIMUS, Department of Pharmacology, School of Pharmacy, Universidad de Santiago de Compostela, Spain.
Life Sci. 1995;56(9):PL187-93. doi: 10.1016/0024-3205(94)00505-m.
Experiments were conducted to evaluate the effects of chronic buspirone (1 mg/kg/day) on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice exposed to a chronic auditory stressor. Treatment with buspirone resulted in a decrease of the stress-induced increase of virus titers and pulmonary vascular permeability as well as in a reduction of the mortality of mice.
进行实验以评估慢性给予丁螺环酮（1毫克/千克/天）对暴露于慢性听觉应激源的CD-1小鼠甲型流感（PR-8/34）病毒特异性免疫损伤的影响。丁螺环酮治疗导致应激诱导的病毒滴度和肺血管通透性增加有所降低，同时小鼠死亡率也有所降低。
