Pamphlett R, Kril J, Hng T M
Department of Pathology (Neuropathology Division), University of Sydney, Australia.
Muscle Nerve. 1995 Mar;18(3):314-8. doi: 10.1002/mus.880180308.
It has been suggested that the primary site of damage in motor neuron disease (MND) is the cortical motor neuron, with secondary degeneration of spinal motor neurons. To test this hypothesis, we sought to determine if loss of corticomotoneurons in MND precedes spinal motor neuron loss. The density of corticomotoneurons was measured in 18 MND and 9 control cases using 10-microns horizontal sections of motor cortex in the hand/arm region. The density of spinal motor neurons was measured in 10-microns transverse sections of the lower cervical spinal cord. Corticomotoneuron and spinal motor neuron densities were decreased in MND cases compared to controls, but in MND cases there was poor correlation (r2 = 0.06) between corticomotoneuron and spinal motor neuron densities. The results indicate that corticomotoneuron and spinal motor neurons are lost at different rates in different MND patients, and that corticomoteneuron loss is unlikely to be a primary event in MND.
有人提出，运动神经元病（MND）的主要损伤部位是皮质运动神经元，继发脊髓运动神经元变性。为验证这一假说，我们试图确定MND中皮质运动神经元的丧失是否先于脊髓运动神经元的丧失。使用手部/臂部区域运动皮质的10微米水平切片，测量了18例MND患者和9例对照者的皮质运动神经元密度。使用下颈段脊髓的10微米横切片，测量了脊髓运动神经元的密度。与对照组相比，MND患者的皮质运动神经元和脊髓运动神经元密度均降低，但在MND患者中，皮质运动神经元和脊髓运动神经元密度之间的相关性较差（r2 = 0.06）。结果表明，在不同的MND患者中，皮质运动神经元和脊髓运动神经元以不同的速率丧失，并且皮质运动神经元的丧失不太可能是MND中的原发性事件。
