抗炎药物与胃肠道出血：阿司匹林和布洛芬的比较
Antiinflammatory drugs and gastrointestinal bleeding: a comparison of aspirin and ibuprofen.
作者信息
Schmid F R, Culic D D
出版信息
J Clin Pharmacol. 1976 Aug-Sep;16(8-9):418-25. doi: 10.1002/j.1552-4604.1976.tb02416.x.
Abstract
Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one year on drug, aspirin consistently caused more bleeding than ibuprofen.
摘要
对类风湿性关节炎患者比较了阿司匹林和布洛芬短期及长期治疗引发的胃肠道失血情况。通过输注51Cr标记的自体红细胞后对四天粪便收集物进行同位素计数来评估失血量。用药两周后或用药一年后，阿司匹林始终比布洛芬导致更多出血。
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