Pemberton R E, Strand L J
Dig Dis Sci. 1979 Jan;24(1):53-64. doi: 10.1007/BF01297239.
Newer nonsteroidal antiinflammatory agents (NSAI's) such as ibuprofen, neproxen, fenoprofen, and tolmetin have broadened the therapeutic choice and increased the chances of providing optimum arthritis control, but require careful assessment of the possibilities for unwanted drug effects when long-term therapy is required. A review of the literature on the gastrointestinal effects of the promising newer NSAIs, as compared with the older agents, aspirin, indomethacin, and phenylbutazone, is presented, highlighting animal toxicology and human adverse reaction surveillance data and the evidence for various suggested pathophysiological mechanisms.
较新的非甾体抗炎药（NSAI），如布洛芬、萘普生、非诺洛芬和托美丁，拓宽了治疗选择，增加了实现最佳关节炎控制的机会，但在需要长期治疗时，需要仔细评估出现药物不良反应的可能性。本文综述了与较老的药物阿司匹林、吲哚美辛和保泰松相比，有前景的新型NSAI对胃肠道影响的文献，重点介绍了动物毒理学和人类不良反应监测数据，以及各种提出的病理生理机制的证据。
