Gretz N
Division of Nephrology, University of Heidelberg, Klinikum Mannheim, Germany.
Nephron. 1994;68(4):462-7. doi: 10.1159/000188308.
Recently, the existence of a rat strain exhibiting autosomal dominant polycystic kidney disease (PKD) resembling human PKD has been described. An exact description of the course of chronic renal failure in this strain, however, is still missing. Thus the aim of this study was to analyze the long-term course of renal failure in these rats. In addition, unilateral nephrectomy (UNX) was performed in order to evaluate the impact of UNX on the occurrence of uremia. Our data clearly revealed that 70-80% of all animals of this rat strain developed uremia within 21 months. Additionally, proteinuria and hypercholesterolemia occurred, while the blood pressure was fairly unaffected. Also a slight degree of anemia was noted. In this long-term study death was due to uremia. The median survival time was significantly shorter in UNX PKD (median 11.6 months) than in non-UNX PKD animals (17.0 months; log-rank test: p = 0.001).
with respect to renal function this rat model resembles human PKD disease. Furthermore, we could demonstrate that UNX is suitable to accelerate the rate of progression of renal failure in this model.
最近，已描述了一种表现出类似于人类常染色体显性多囊肾病（PKD）的大鼠品系的存在。然而，关于该品系慢性肾衰竭病程的准确描述仍然缺失。因此，本研究的目的是分析这些大鼠肾衰竭的长期病程。此外，进行了单侧肾切除术（UNX），以评估UNX对尿毒症发生的影响。我们的数据清楚地显示，该大鼠品系中70 - 80%的动物在21个月内发展为尿毒症。此外，出现了蛋白尿和高胆固醇血症，而血压基本未受影响。还观察到轻度贫血。在这项长期研究中，死亡原因是尿毒症。UNX PKD组的中位生存时间（中位11.6个月）明显短于非UNX PKD动物（17.0个月；对数秩检验：p = 0.001）。
就肾功能而言，该大鼠模型类似于人类PKD疾病。此外，我们可以证明UNX适合加速该模型中肾衰竭的进展速度。
