Nevins M E, Nash S A, Beardsley P M
Department of Neurological Diseases Research, Searle, Skokie, IL 60077.
Psychopharmacology (Berl). 1993;110(1-2):92-6. doi: 10.1007/BF02246955.
The effects of various centrally acting drugs and some peripherally acting agents on the forelimb grip strength of CD-1 mice were explored. Forelimb grip strength was assessed by use of a strain gauge to measure the lateral pull force, in grams, exerted by mice as an index of muscle relaxation. The muscle relaxants, diazepam, midazolam, baclofen, methocarbamol, dantrolene sodium and the neuromuscular blocking agents, succinylcholine and pancuronium bromide, dose-dependently reduced forelimb grip strength. 2-Amino-7-phosphonoheptanoic acid (AP7), which has also been shown to have muscle relaxant effects, also reduced grip strength. Pentobarbital, ethanol, phencyclidine, ketamine and chlorpromazine reduced grip strength at doses which produced behavioral impairments. Lithium chloride, a toxic compound used to induce taste aversions, and clonidine, at doses which affect blood pressure, body temperature and locomotor activity, did not affect grip strength. In addition, stimulant doses of amphetamine and caffeine, but not of morphine, increased grip strength in a dose-dependent manner. These results extend previous findings and suggest that this forelimb grip strength procedure may be a useful screening test for the identification of the potential muscle relaxant properties of drugs.
研究了各种中枢作用药物和一些外周作用药物对CD-1小鼠前肢握力的影响。使用应变仪测量小鼠施加的横向拉力（以克为单位）来评估前肢握力，以此作为肌肉松弛的指标。肌肉松弛剂地西泮、咪达唑仑、巴氯芬、美索巴莫、丹曲林钠以及神经肌肉阻滞剂琥珀酰胆碱和泮库溴铵，均剂量依赖性地降低前肢握力。2-氨基-7-膦酰庚酸（AP7）也已被证明具有肌肉松弛作用，它也降低了握力。戊巴比妥、乙醇、苯环己哌啶、氯胺酮和氯丙嗪在产生行为损伤的剂量下降低了握力。用于诱导味觉厌恶的有毒化合物氯化锂以及在影响血压、体温和运动活动的剂量下的可乐定，均未影响握力。此外，兴奋剂剂量的苯丙胺和咖啡因可剂量依赖性地增加握力，但吗啡则无此作用。这些结果扩展了先前的发现，并表明这种前肢握力测试方法可能是一种有用的筛选试验，用于鉴定药物潜在的肌肉松弛特性。
