Narita M, Takahashi Y, Suzuki T, Misawa M, Nagase H
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Psychopharmacology (Berl). 1993;110(4):500-2. doi: 10.1007/BF02244659.
ICV bicuculline, a selective GABAA antagonist, dose-dependently induced clonic-tonic convulsions in mice. Coadministration of ICV morphine (mu opioid agonist) significantly potentiated ICV bicuculline-induced convulsions, and this effect of morphine was completely blocked by pretreatment with beta-funaltrexamine (beta-FNA), a mu antagonist. ICV glibenclamide, a selective ATP-sensitive potassium (KATP) channel blocker, at a dose which alone did not affect the convulsive threshold of bicuculline, was capable of blocking the exacerbation of ICV bicuculline-induced convulsions by morphine. The present data further suggest that KATP channels may play a tonic regulatory role in the potentiative effect of morphine on ICV bicuculline-induced convulsions.
脑室内注射荷包牡丹碱（一种选择性GABAA拮抗剂）可使小鼠产生剂量依赖性的阵挛 - 强直性惊厥。同时脑室内注射吗啡（μ阿片受体激动剂）可显著增强脑室内注射荷包牡丹碱所致的惊厥，且吗啡的这一作用可被μ拮抗剂β - 氟纳曲明（β - FNA）预处理完全阻断。脑室内注射格列本脲（一种选择性ATP敏感性钾通道阻滞剂），其单独使用时不影响荷包牡丹碱的惊厥阈值，但能够阻断吗啡对脑室内注射荷包牡丹碱所致惊厥的加剧作用。目前的数据进一步表明，ATP敏感性钾通道可能在吗啡对脑室内注射荷包牡丹碱所致惊厥的增强作用中发挥着紧张性调节作用。
