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中枢ATP敏感性钾通道在小鼠吗啡热效应中的作用。

Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice.

作者信息

Narita M, Suzuki T, Misawa M, Nagase H

机构信息

Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

出版信息

Psychopharmacology (Berl). 1992;109(1-2):239-40. doi: 10.1007/BF02245507.

DOI:10.1007/BF02245507
PMID:1365664
Abstract

Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 micrograms, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of mu agonists.

摘要

与脑室内注射赋形剂加皮下注射生理盐水（对照组）相比，皮下注射吗啡（10毫克/千克）与脑室内注射赋形剂联合使用，在注射后120分钟（峰值时间）引起显著的体温升高效应。格列本脲（50微克，脑室内注射），一种选择性三磷酸腺苷敏感性钾（KATP）通道阻滞剂，与皮下注射生理盐水联合使用时，与对照组相比几乎不影响直肠温度。脑室内注射格列本脲以剂量依赖性方式拮抗皮下注射吗啡诱导的体温升高。从这些结果来看，我们证明KATP通道作为μ激动剂体温升高效应的调节因子发挥着重要作用。

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本文引用的文献

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Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.清醒小鼠脑内注射药物所产生的药理效应。
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激活中枢ATP敏感性钾通道可产生小鼠抗伤害感受及增强脊髓去甲肾上腺素更新率的效应。
Psychopharmacology (Berl). 1993;113(1):11-4. doi: 10.1007/BF02244326.
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Alteration of thermoregulatory set point with opioid agonists.阿片类激动剂对体温调节设定点的改变。
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Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.葡萄糖、磺脲类药物与神经递质释放：ATP敏感性钾通道的作用
Science. 1990 Feb 16;247(4944):852-4. doi: 10.1126/science.2305257.
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An ATP-dependent potassium channel blocker antagonizes morphine analgesia.一种ATP依赖性钾通道阻滞剂可拮抗吗啡镇痛作用。
Eur J Pharmacol. 1990 Sep 21;186(2-3):377-8. doi: 10.1016/0014-2999(90)90466-j.
9
Sulfonylurea binding sites associated with ATP-regulated K+ channels in the central nervous system: autoradiographic analysis of their distribution and ontogenesis, and of their localization in mutant mice cerebellum.中枢神经系统中与ATP调节的钾通道相关的磺酰脲结合位点：其分布、个体发生及其在突变小鼠小脑中定位的放射自显影分析
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10
Opioid delta receptor subtypes are associated with different potassium channels.阿片δ受体亚型与不同的钾通道相关。
Eur J Pharmacol. 1991 Jan 25;193(1):135-6. doi: 10.1016/0014-2999(91)90215-c.