中枢ATP敏感性钾通道在小鼠吗啡热效应中的作用。
Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice.
作者信息
Narita M, Suzuki T, Misawa M, Nagase H
机构信息
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
出版信息
Psychopharmacology (Berl). 1992;109(1-2):239-40. doi: 10.1007/BF02245507.
Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 micrograms, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of mu agonists.
与脑室内注射赋形剂加皮下注射生理盐水（对照组）相比，皮下注射吗啡（10毫克/千克）与脑室内注射赋形剂联合使用，在注射后120分钟（峰值时间）引起显著的体温升高效应。格列本脲（50微克，脑室内注射），一种选择性三磷酸腺苷敏感性钾（KATP）通道阻滞剂，与皮下注射生理盐水联合使用时，与对照组相比几乎不影响直肠温度。脑室内注射格列本脲以剂量依赖性方式拮抗皮下注射吗啡诱导的体温升高。从这些结果来看，我们证明KATP通道作为μ激动剂体温升高效应的调节因子发挥着重要作用。
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