Catteau B, Delaporte E, Hachulla E, Piette F, Bergoend H
Service de dermatologie A, Hôpital Claude-Huriez, Lille, France.
Rev Med Interne. 1995;16(1):10-4. doi: 10.1016/0248-8663(96)80659-x.
We report two cases of Mycoplasma pneumoniae infections associated with Stevens-Johnson syndrome and antiphospholipid antibodies. Such an association has been noted once in the literature. The relationship between antiphospholipid antibodies and Stevens-Johnson syndrome and others cutaneous manifestations of infections diseases is discussed. Though mainly described in systemic lupus erythematosus and autoimmune diseases, anticardiolipin antibodies and lupus anticoagulant have been found in many infectious disorders. But in the latter conditions, they have been considered by many authors as "non pathogenic" or "non prothrombotic" on epidemiologic and immunologic data. We suggest that antiphospholipid antibodies could possibly play a role in their pathogenesis especially as the mechanisms are not to date clearly understood.
我们报告了两例与史蒂文斯-约翰逊综合征及抗磷脂抗体相关的肺炎支原体感染病例。这种关联在文献中仅被提及过一次。本文讨论了抗磷脂抗体与史蒂文斯-约翰逊综合征以及其他感染性疾病皮肤表现之间的关系。虽然抗心磷脂抗体和狼疮抗凝物主要在系统性红斑狼疮及自身免疫性疾病中被描述,但在许多感染性疾病中也有发现。不过,在这些感染性疾病中,许多作者基于流行病学和免疫学数据认为它们是“无致病性的”或“非促血栓形成的”。我们认为抗磷脂抗体可能在其发病机制中发挥作用,尤其是鉴于目前其机制尚未完全明确。