Oltmer S, von Engelhardt W
Dept. of Physiology, School of Veterinary Medicine, Hanover, Germany.
Scand J Gastroenterol. 1994 Nov;29(11):1009-16. doi: 10.3109/00365529409094878.
Short-chain fatty acids (SCFA) originate from microbial fermentation of carbohydrates in the hindgut. Mechanisms involved in SCFA absorption are not fully understood.
The caecum and proximal and distal colon of the guinea pig were perfused in situ.
SCFA absorption per gram mucosal dry weight was highest in the proximal colon and lowest in the caecum. Owing to the large surface, quantitatively SCFA absorption was highest from the caecum. In the distal colon clearance of SCFA increased with chain length (Ac < Pr < Bu); in the caecum and proximal colon only a comparatively small or no such influence was observed. Inhibition of the proton antiport systems in the apical membrane and inhibition of the carbonic anhydrase activity diminished SCFA absorption. The diffusive and carrier components of absorption were calculated for propionate at increasing propionate concentrations.
Marked segmental differences in SCFA absorption are apparent in the large intestine of the guinea pig.
短链脂肪酸（SCFA）源于后肠中碳水化合物的微生物发酵。SCFA吸收所涉及的机制尚未完全明确。
对豚鼠的盲肠以及近端和远端结肠进行原位灌注。
每克黏膜干重的SCFA吸收量在近端结肠最高，在盲肠最低。由于表面积大，从盲肠的SCFA吸收量在数量上最高。在远端结肠，SCFA的清除率随链长增加（乙酸＜丙酸＜丁酸）；在盲肠和近端结肠，仅观察到相对较小的影响或没有此类影响。顶端膜中质子反向转运系统的抑制以及碳酸酐酶活性的抑制会减少SCFA的吸收。在丙酸浓度增加时计算了丙酸吸收的扩散和载体成分。
豚鼠大肠中SCFA吸收存在明显的节段性差异。
