Mevissen M, Buntenkötter S, Löscher W
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany.
Teratology. 1994 Sep;50(3):229-37. doi: 10.1002/tera.1420500308.
Mated Wistar rats were chronically exposed to a static magnetic field (MF) from day 1 to day 20 of pregnancy. Flux density of the MF was 30 mTesla (mT), i.e., within the range of exposures of operators of magnetic resonance imaging (MRI) devices. For comparison with effects of this static field, a time-varying (50-Hz) MF of the same flux density was used. In both experiments, i.e., static or 50-Hz MF exposure, sham-exposed groups of dams served as controls. On day 20, the dams were sacrificed for reproductive and teratological assessment. The litters were evaluated for numbers of implantations, fetal deaths and resorptions, gross external, visceral, and skeletal malformations, and fetal weights. No adverse effects were seen in the dams during MF exposure. The mean number of living fetuses per litter was significantly decreased in the group with static MF exposure, but not the group with 50-Hz MF exposure. Further differences between the two types of field exposure were observed with respect to minor (skeletal) fetal anomalies which were increased in the 50-Hz but not the static MF group. No serious malformations were seen in any group. In both MF-exposed groups, increased skeletal ossification was found, possibly indicating an accelerated prenatal development. In a second experiment with static MF (30 mT) in which dams were exposed for the whole period of pregnancy, and postnatal growth and development of offspring were studied, the postnatal growth was significantly enhanced in offspring following their prenatal MF exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
将妊娠第1天至第20天的Wistar交配大鼠长期暴露于静磁场（MF）中。该静磁场的通量密度为30毫特斯拉（mT），即在磁共振成像（MRI）设备操作人员的暴露范围内。为了与该静磁场的效应进行比较，使用了相同通量密度的时变（50赫兹）MF。在这两个实验中，即静磁场或50赫兹MF暴露实验中，假暴露的母鼠组作为对照。在第20天，处死母鼠以进行生殖和致畸评估。对窝仔进行植入数、胎儿死亡和吸收情况、大体外观、内脏和骨骼畸形以及胎儿体重的评估。在MF暴露期间，母鼠未出现不良反应。静磁场暴露组每窝存活胎儿的平均数量显著减少，但50赫兹MF暴露组未出现这种情况。在轻微（骨骼）胎儿异常方面观察到两种场暴露之间的进一步差异，50赫兹MF组的此类异常增加，而静磁场组未增加。任何组均未出现严重畸形。在两个MF暴露组中，均发现骨骼骨化增加，这可能表明产前发育加速。在第二项静磁场（30 mT）实验中，母鼠在整个孕期暴露，研究后代的出生后生长和发育，产前MF暴露后代的出生后生长显著增强。（摘要截断于250字）
