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Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid.

作者信息

Moore S A

机构信息

Department of Pathology, University of Iowa, Iowa City.

出版信息

World Rev Nutr Diet. 1994;75:128-33. doi: 10.1159/000423566.

DOI:10.1159/000423566
PMID:7871814
Abstract
摘要

相似文献

1
Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid.
World Rev Nutr Diet. 1994;75:128-33. doi: 10.1159/000423566.
2
Cerebral endothelium and astrocytes cooperate in supplying docosahexaenoic acid to neurons.脑内皮细胞和星形胶质细胞协同作用，为神经元提供二十二碳六烯酸。
Adv Exp Med Biol. 1993;331:229-33. doi: 10.1007/978-1-4615-2920-0_36.
3
Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors.血脑屏障在由必需脂肪酸前体形成长链ω-3和ω-6脂肪酸过程中的作用。
J Neurochem. 1990 Aug;55(2):391-402. doi: 10.1111/j.1471-4159.1990.tb04150.x.
4
Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid.在喂食低亚麻酸饮食并补充二十二碳六烯酸的雏鸡大脑和视网膜中n-3脂肪酸的积累。
Am J Clin Nutr. 1994 Jun;59(6):1338-46. doi: 10.1093/ajcn/59.6.1338.
5
Astrocytes, not neurons, produce docosahexaenoic acid (22:6 omega-3) and arachidonic acid (20:4 omega-6).星形胶质细胞而非神经元产生二十二碳六烯酸（22:6 ω-3）和花生四烯酸（20:4 ω-6）。
J Neurochem. 1991 Feb;56(2):518-24. doi: 10.1111/j.1471-4159.1991.tb08180.x.
6
Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro.脑源细胞在体外合成及释放多不饱和脂肪酸
J Mol Neurosci. 2001 Apr-Jun;16(2-3):195-200; discussion 215-21. doi: 10.1385/JMN:16:2-3:195.
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Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats.大鼠膳食 ALA 干预后血液和组织中 ω-3 LCPUFA 状态的相关性。
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):53-60. doi: 10.1016/j.plefa.2012.04.005. Epub 2012 Apr 20.
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Importance of n-3 fatty acids in health and disease.n-3脂肪酸在健康与疾病中的重要性。
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Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids.二十二碳六烯酸（DHA）可由α-亚麻酸合成，但富含多不饱和脂肪酸的饮食会抑制其合成。
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):139-46. doi: 10.1016/j.plefa.2012.04.003. Epub 2012 Apr 17.
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The role of dietary n-6 and n-3 fatty acids in the developing brain.膳食中n-6和n-3脂肪酸在大脑发育中的作用。
Dev Neurosci. 2000 Sep-Dec;22(5-6):474-80. doi: 10.1159/000017478.

引用本文的文献

1
Docosahexaenoic Acid (DHA) Induced Morphological Differentiation of Astrocytes Is Associated with Transcriptional Upregulation and Endocytosis of β-AR.二十二碳六烯酸（DHA）诱导星形胶质细胞形态分化与β-AR 的转录上调和内吞作用有关。
Mol Neurobiol. 2019 Apr;56(4):2685-2702. doi: 10.1007/s12035-018-1260-0. Epub 2018 Jul 27.
2
Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A in a spatial-specific manner.寡聚淀粉样β以空间特异性方式诱导脑胞质和钙非依赖性磷脂酶 A 的 MAPK 介导的激活。
Acta Neuropathol Commun. 2017 Jul 27;5(1):56. doi: 10.1186/s40478-017-0460-6.
3
Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue.
脑组织中的缩醛磷脂、磷脂酶A2和二十二碳六烯酸代谢
J Mol Neurosci. 2001 Apr-Jun;16(2-3):263-72; discussion 279-84. doi: 10.1385/jmn:16:2-3:263.
4
Docosahexaenoic acid accumulation in the prenatal brain: prooxidant and antioxidant features.产前大脑中二十二碳六烯酸的积累：促氧化和抗氧化特性。
J Mol Neurosci. 2001 Apr-Jun;16(2-3):229-35; discussion 279-84. doi: 10.1385/JMN:16:2-3:229.
5
Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells.二十二碳六烯酸（DHA）摄取并掺入神经元细胞体以及神经突/神经生长锥脂质中：在神经生长因子分化的PC12细胞中DHA代谢区室化的证据。
Neurochem Res. 2000 May;25(5):715-23. doi: 10.1023/a:1007575406896.
6
Dietary alpha-linolenic acid increases the biosynthesis of the choline glycerophospholipids from [14C]CDPcholine in rat liver and kidney but not in brain.膳食中的α-亚麻酸可增加大鼠肝脏和肾脏中由[14C]CDP胆碱合成胆碱甘油磷脂的过程，但对大脑无此作用。
Neurochem Res. 1997 Oct;22(10):1291-7. doi: 10.1023/a:1021945316218.
7
Role of essential fatty acids in the function of the developing nervous system.必需脂肪酸在发育中的神经系统功能中的作用。
Lipids. 1996 Mar;31 Suppl:S167-76. doi: 10.1007/BF02637071.