tho Pesch S, Müller W, Borchard F, Peters U
Innere Abteilung Krankenhaus Maria Hilf, Krefeld.
Z Gastroenterol. 1994 Dec;32(12):684-7.
A 63 year old patient came to admission because of abdominal pain. A stone disease of the gallbladder was known. Gastroscopy showed active gastritis of the antral-mucosa with some erosive lesions. Histology revealed surprisingly a low grade MALT lymphoma. Helicobacter pylori colonization (H. pylori) was found in the mucosa. While additional lymphomas were not found, a therapy aiming at the eradication of H. pylori was started. A subsequent control biopsy showed only slight lymphoplasmacellular inflammatory infiltration of the mucosa but no evidence of lymphoma. Our case report shows, that regression of a gastric MALT lymphoma can be achieved by eradication of H. pylori only. So far we don't know for how long this regression will continue and if permanent healing is possible. Further studies will have to show whether eradication of H. pylori can be established as a new therapeutic concept of low-grade MALT lymphomas at early stages.
一名63岁的患者因腹痛入院。已知患有胆囊结石病。胃镜检查显示胃窦黏膜有活动性胃炎，并伴有一些糜烂性病变。组织学检查令人惊讶地发现是低级别黏膜相关淋巴组织（MALT）淋巴瘤。在黏膜中发现了幽门螺杆菌定植（H. pylori）。虽然未发现其他淋巴瘤，但开始了旨在根除幽门螺杆菌的治疗。随后的对照活检显示黏膜仅有轻微的淋巴浆细胞炎性浸润，但无淋巴瘤证据。我们的病例报告表明，仅通过根除幽门螺杆菌就可以实现胃MALT淋巴瘤的消退。到目前为止，我们不知道这种消退会持续多久以及是否可能实现永久性治愈。进一步的研究将不得不表明，根除幽门螺杆菌是否可以确立为早期低级别MALT淋巴瘤的一种新的治疗理念。
