Cammarota G, Tursi A, Cannizzaro O, Papa A, Cuoco L, Cianci R, Fedeli P, Fedeli G, Gasbarrini G
Department of Internal Medicine, University of Rome, Italy.
Ital J Gastroenterol Hepatol. 1997 Aug;29(4):361-4.
Some studies have suggested that low-grade MALT lymphoma may regress after eradication of Helicobacter pylori infection. This case report describes a Helicobacter pylori-positive patient with very extensive ulcerated polypoid lesions involving gastric antrum and prepyloric region, diagnosed by histology, pathological analysis and staging procedures as low-grade MALT lymphoma of EI1 stage. The patient received eradication therapy with a one-week course of omeprazole plus amoxicillin plus clarithromycin and was seen at follow-up after 3, 6 and 15 months. At follow-up, Helicobacter pylori eradication appeared to be in resolution of the macroscopic and histological features of the lymphoma, as confirmed by endoscopic, histological and molecular findings. Until now, only a few cases with a large gastric MALT lymphoma has successful treatment of Helicobacter pylori resulted in regression. Although additional follow-up is needed, it would appear that Helicobacter pylori infection cure may be effective also for large low-grade stage EI1 MALT lymphoma.
一些研究表明，根除幽门螺杆菌感染后，低度黏膜相关淋巴组织（MALT）淋巴瘤可能会消退。本病例报告描述了一名幽门螺杆菌阳性患者，其胃窦和幽门前区域有非常广泛的溃疡性息肉样病变，经组织学、病理分析和分期程序诊断为EI1期低度MALT淋巴瘤。该患者接受了为期一周的奥美拉唑加阿莫西林加克拉霉素根除治疗，并在3个月、6个月和15个月后进行随访。随访时，内镜、组织学和分子检查结果证实，幽门螺杆菌根除似乎使淋巴瘤的宏观和组织学特征得到缓解。到目前为止，只有少数大的胃MALT淋巴瘤病例成功治疗幽门螺杆菌后出现消退。虽然还需要进一步随访，但似乎幽门螺杆菌感染的治愈对大的低度EI1期MALT淋巴瘤也可能有效。
