Martino R, Nomdedéu J, Sureda A, Mateu R, Brunet S, Domingo-Albós A
Department of Hematology, Hospital de La Santa Creu i Sant Pau, Barcelona, Spain.
Acta Haematol. 1994;92(3):140-1. doi: 10.1159/000204204.
A 20-year-old male underwent an allogeneic bone marrow transplantation for acute myelogenous leukemia after conditioning with cyclophosphamide and total body irradiation. On day +6 of the procedure, he developed fever, chills and myalgias. Empiric treatment with ceftazidime and amikacin was begun, and blood cultures grew viridans streptococci. Biochemical changes suggestive of acute rhabdomyolysis were evident. Within 24 h, adult respiratory distress syndrome with multiorgan failure appeared, and he died 7 days later. At autopsy, the presence of rhabdomyolysis was confirmed.
一名20岁男性在接受环磷酰胺和全身照射预处理后，因急性髓细胞白血病接受了异基因骨髓移植。在移植术后第6天，他出现发热、寒战和肌痛。开始使用头孢他啶和阿米卡星进行经验性治疗，血培养结果显示为草绿色链球菌生长。提示急性横纹肌溶解的生化改变很明显。在24小时内，出现了伴有多器官功能衰竭的成人呼吸窘迫综合征，7天后他死亡。尸检证实存在横纹肌溶解。
