Undar L, Karadoğan I, Artvinli M, Karpuzoğlu G
Department of Hematology, Akdeniz University School of Medicine, Antalya, Turkey.
Acta Haematol. 1994;92(3):150-3. doi: 10.1159/000204208.
Werner's syndrome is a relatively rare autosomal recessive disorder characterized by several features generally associated with aging. This syndrome is classified in the group of chromosome instability syndromes and there is an increased incidence of neoplasia. Hematologic malignancies associated with this syndrome are, however, unusual. Herein we report a case of Werner's syndrome with myelodysplastic syndrome, a clonal preleukemic disorder of hemopoietic stem cells. Such an association, to the best of our knowledge, has not been reported in the English literature so far.
沃纳综合征是一种相对罕见的常染色体隐性疾病，其特征为具有一些通常与衰老相关的特点。该综合征归类于染色体不稳定综合征组，且肿瘤发生率增加。然而，与该综合征相关的血液系统恶性肿瘤并不常见。在此，我们报告一例沃纳综合征合并骨髓增生异常综合征的病例，骨髓增生异常综合征是造血干细胞的一种克隆性白血病前期疾病。据我们所知，迄今为止英文文献中尚未报道过这种关联。
