Puchner R, Steglegger-Friede B, Roithinger F X, Knoflach P
Abteilung für Innere Medizin I, Krankenhauses der Barmherzigen Schwestern vom Heiligen, Kreuz, Wels.
Acta Med Austriaca. 1994;21(4):107-10.
30 patients with rheumatoid arthritis were treated with a weekly low dose of Methotrexate for a period of 12 months. In the course of treatment there was significant improvement in pain and mobility, in the number of inflamed joints and use of steroids. There was a fall in erythrocyte sedimentation rate and hemoglobin content rose significantly. 81% of the patients improved. Of these 14% had a complete clinical remission. There were 19% non-responders. Adverse reactions developed in 13 patients (43.3%, gastrointestinal symptoms, elevated liver enzymes, loss of hair, stomatitis). After decreasing or temporary discontinuing in 10 of them the drug was taken again later on. It had to be withdrawn in 3 patients (10%). All recovered when Methotrexate was discontinued. It is concluded that low dose Methotrexate is effective in the long term treatment of chronic rheumatoid arthritis.
30例类风湿性关节炎患者接受每周低剂量甲氨蝶呤治疗，为期12个月。在治疗过程中，疼痛和活动能力、炎症关节数量以及类固醇的使用情况均有显著改善。红细胞沉降率下降，血红蛋白含量显著上升。81%的患者病情好转。其中14%实现了完全临床缓解。有19%的患者无反应。13例患者（43.3%）出现不良反应（胃肠道症状、肝酶升高、脱发、口腔炎）。其中10例患者在减少剂量或暂时停药后，后来又重新服用该药物。3例患者（10%）不得不停药。停用甲氨蝶呤后，所有患者均康复。结论是低剂量甲氨蝶呤在慢性类风湿性关节炎的长期治疗中有效。
