Yao Q P, Zhang N Z
Peking Union Medical College Hospital, Beijing.
Yao Xue Xue Bao. 1994;29(10):790-2.
The effects of tripchlorolide, an active ingredient (T4) of Tripterygium wilfordii Hook on the production of prostaglandin E2(PGE2) by synovial cells of rheumatoid arthritis (RA) patients were investigated. Six cases of definite RA (female 5, male 1, mean age 45 with an average course of disease of 9 years) were selected. Surgically obtained synovium specimen were dissociated into digested synovial single cells (DSSC). The cells were incubated with various concentrations of T4 for 48 hours. Using radioimmunoassay T4 was found to significantly inhibit the production of PGE2 (control 6.10 +/- 2.30 vs T4 treated 0.58 +/- 0.47 x 10(-5) mol.L-1) by short-term cultured DSSC of RA patients. The results of this study suggests that T4 may be useful in the forthcoming treatment of RA due to its inhibition of production of PGE2 by synovial cells.
研究了雷公藤有效成分雷公藤甲素（T4）对类风湿关节炎（RA）患者滑膜细胞前列腺素E2（PGE2）产生的影响。选取6例确诊的RA患者（女性5例，男性1例，平均年龄45岁，平均病程9年）。手术获取的滑膜标本解离为消化后的滑膜单细胞（DSSC）。将细胞与不同浓度的T4孵育48小时。采用放射免疫分析法发现，T4能显著抑制RA患者短期培养的DSSC产生PGE2（对照组6.10 +/- 2.30，T4处理组0.58 +/- 0.47 x 10(-5) mol.L-1）。本研究结果表明，T4可能因其对滑膜细胞产生PGE2的抑制作用而对即将到来的RA治疗有用。
