McKinley M J, Rundgren M, Coghlan J P
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Acta Physiol Scand. 1994 Nov;152(3):323-32. doi: 10.1111/j.1748-1716.1994.tb09812.x.
A centrally mediated inhibitory influence of plasma hypertonicity on renin secretion was investigated in conscious, Na-depleted sheep. Infusions of hypertonic solutions were made into the carotid artery or jugular vein, and the effects on plasma renin concentration (PRC) compared. Intracarotid infusion of 1.65 M NaCl significantly reduced PRC (to 74% of the pre-infusion value) within 15 min of the commencement of the infusion whereas corresponding intrajugular infusion did not. Intracarotid infusion of 3 M sorbitol for 45 min also reduced PRC (to 64% of the pre-infusion level) significantly after 15 min of infusion. By contrast, neither intrajugular infusion of 3 M sorbitol, nor intracarotid infusion of isotonic 0.15 M NaCl for 45 min significantly reduced PRC. Intracarotid infusion of hypertonic sorbitol for 45 min did not inhibit PRC in sheep with cerebral lesions of the lamina terminalis. These results show that plasma hypertonicity may have an inhibitory influence on renin secretion. The inhibition is probably mediated by an effect of hypertonicity on the CNS, rather than a direct effect on the kidney.
在清醒、缺钠的绵羊中研究了血浆高渗对肾素分泌的中枢介导抑制作用。将高渗溶液注入颈动脉或颈静脉，并比较其对血浆肾素浓度（PRC）的影响。颈动脉内注入1.65M NaCl在注入开始后15分钟内显著降低PRC（降至注入前值的74%），而相应的颈静脉内注入则没有。颈动脉内注入3M山梨醇45分钟，在注入15分钟后也显著降低PRC（降至注入前水平的64%）。相比之下，颈静脉内注入3M山梨醇或颈动脉内注入等渗的0.15M NaCl 45分钟均未显著降低PRC。在终板层有脑损伤的绵羊中，颈动脉内注入高渗山梨醇45分钟并未抑制PRC。这些结果表明，血浆高渗可能对肾素分泌有抑制作用。这种抑制可能是由高渗对中枢神经系统的作用介导的，而不是对肾脏的直接作用。
