Ericson A C, Lindbom L O, Ulfendahl H R
Acta Physiol Scand. 1976 Sep;98(1):19-23. doi: 10.1111/j.1748-1716.1976.tb10297.x.
On male Sprague Dawley rats isotonic NaCl during control and 1 M NaCl were infused either into the carotid artery or i.v. Glomerular filtration rate, sodium output and plasma renin activity were determined. Five of 19 animals reacted with no increase in sodium output for 1 M NaCl and are treated as a different group from the animals reacting with an increased sodium output. For the animals reacting with an increased sodium output a decrease in plasma renin activity was found together with an increase in glomerular filtration rate. In both groups the plasma sodium was constant. The animals not reacting with an increased sodium output had a higher initial plasma renin activity, which did not change during 1 M NaCl infusion. The responses were equal for both intracarotid and i.v. infusions but with a somewhat longer delay before the response occurred with i.v. infusions. These results might be explained by a central nervous effect and by a direct renal effect. Also during 1 M NaCl infusion a possible extracellular volume expansion, derived from water withdrawal from the cells into the extracellular space might occur.
在雄性斯普拉格-道利大鼠身上，在对照期向颈动脉或静脉内输注等渗氯化钠溶液，然后输注1M氯化钠溶液。测定肾小球滤过率、钠排出量和血浆肾素活性。19只动物中有5只对1M氯化钠溶液无钠排出量增加反应，被视为与有钠排出量增加反应的动物不同的一组。对于有钠排出量增加反应的动物，发现血浆肾素活性降低，同时肾小球滤过率增加。两组动物的血浆钠均保持恒定。对1M氯化钠溶液无钠排出量增加反应的动物初始血浆肾素活性较高，在输注1M氯化钠溶液期间该活性未发生变化。颈动脉内输注和静脉内输注的反应相同，但静脉内输注时反应出现的延迟稍长一些。这些结果可能由中枢神经效应和直接的肾脏效应来解释。在输注1M氯化钠溶液期间，也可能会发生因细胞内水分向细胞外间隙转移而导致的细胞外液量可能的扩张。
