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Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats.

作者信息

Zhao Q, Pahlmark K, Smith M L, Siesjö B K

机构信息

Laboratory for Experimental Brain Research, University of Lund, Sweden.

出版信息

Acta Physiol Scand. 1994 Nov;152(3):349-50. doi: 10.1111/j.1748-1716.1994.tb09816.x.

DOI:10.1111/j.1748-1716.1994.tb09816.x
PMID:7872013
Abstract
摘要

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Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats.在大鼠短暂性大脑中动脉闭塞后，使用自旋捕获剂α-苯基-N-叔丁基硝酮（PBN）进行延迟治疗可减小梗死面积。
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The free radical spin-trap alpha-PBN attenuates periinfarct depolarizations following permanent middle cerebral artery occlusion in rats without reducing infarct volume.自由基自旋捕捉剂α-苯基-N-叔丁基硝酮可减轻大鼠大脑中动脉永久性闭塞后的梗死周围去极化，且不减小梗死体积。
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The effect of alpha-phenyl-tert-butyl nitrone (PBN) on free radical formation in transient focal ischaemia measured by microdialysis and 3,4-dihydroxybenzoate formation.α-苯基叔丁基硝酮（PBN）对通过微透析测量的短暂局灶性缺血中自由基形成及3,4-二羟基苯甲酸形成的影响。
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