抗氧化剂：脑保护转化研究的新前沿。
Antioxidants: The new frontier for translational research in cerebroprotection.
作者信息
Tewari Anurag, Mahendru Vidhi, Sinha Ashish, Bilotta Federico
机构信息
Department of Anesthesiology, Dayanand Medical College, Ludhiana, Punjab, India.
Department of Anesthesiology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
J Anaesthesiol Clin Pharmacol. 2014 Apr;30(2):160-71. doi: 10.4103/0970-9185.130001.
Abstract
It is important for the anesthesiologist to understand the etiology of free radical damage and how free-radical scavengers attenuate this, so that this knowledge can be applied to diverse neuro-pathological conditions. This review will concentrate on the role of reactive species of oxygen in the pathophysiology of organ dysfunction, specifically sub arachnoid hemorrhage (SAH), traumatic brain injury (TBI) as well as global central nervous system (CNS) hypoxic, ischemic and reperfusion states. We enumerate potential therapeutic modalities that are been currently investigated and of interest for future trials. Antioxidants are perhaps the next frontier of translational research, especially in neuro-anesthesiology.
摘要
麻醉医生了解自由基损伤的病因以及自由基清除剂如何减轻这种损伤非常重要，以便将这些知识应用于各种神经病理状况。本综述将集中探讨活性氧在器官功能障碍病理生理学中的作用，特别是蛛网膜下腔出血（SAH）、创伤性脑损伤（TBI）以及全中枢神经系统（CNS）缺氧、缺血和再灌注状态。我们列举了目前正在研究且未来试验感兴趣的潜在治疗方式。抗氧化剂可能是转化研究的下一个前沿领域，尤其是在神经麻醉学方面。
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