Loskove J A, Frishman W H
Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Am Heart J. 1995 Mar;129(3):604-13. doi: 10.1016/0002-8703(95)90291-0.
NO has been shown to be a biologic substance important to normal physiologic functioning. It appears to be an endogenous vasodilator and is involved in hemostasis and inflammation. Endothelial cell dysfunction often leads to diminished NO production; this reduction in NO concentrations may be an etiologic factor in systemic hypertension, myocardial and splanchnic ischemia, atherosclerosis, CHF, and pulmonary vascular disease. A new class of drugs, NO donors, have potential utility in the treatment of coronary and pulmonary arterial diseases. Their major advantage over nitrates and nitroprusside is a lack of pharmacologic tolerance. Clinical trials with drugs of this class are now in progress.
一氧化氮已被证明是一种对正常生理功能很重要的生物物质。它似乎是一种内源性血管舒张剂，参与止血和炎症过程。内皮细胞功能障碍常导致一氧化氮生成减少；一氧化氮浓度的这种降低可能是系统性高血压、心肌和内脏缺血、动脉粥样硬化、心力衰竭和肺血管疾病的一个病因。一类新型药物，即一氧化氮供体，在治疗冠状动脉和肺动脉疾病方面具有潜在用途。它们相对于硝酸盐和硝普钠的主要优势是缺乏药理学耐受性。这类药物的临床试验正在进行中。
