Strauss J F, Steinkampf M P
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104-6142.
Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):726-35. doi: 10.1016/0002-9378(95)90146-9.
During the past decade, research on hypothalamic-pituitary-ovarian relationships in ovulation has explored the contributions of ovarian steroids and other possible ovarian-derived endocrine factors, such as inhibin, follistatin, and activin. Follistatin and activin probably have a significant intraovarian and intrapituitary function but are not likely to have critical endocrine roles during the follicular phase. Studies carried out with both recombinant and highly purified forms of follicle-stimulating hormone in humans and monkeys indicate that this hormone is the primary stimulant of follicular growth and development. Studies on animals may have led to incorrect emphasis on the local role of estradiol in primate follicular growth. It appears that estradiol is not a critical folliculotropin in humans, although it may have some important direct effects on the oocyte.
在过去十年中，关于排卵过程中下丘脑 - 垂体 - 卵巢关系的研究探讨了卵巢类固醇以及其他可能源自卵巢的内分泌因子的作用，如抑制素、卵泡抑素和激活素。卵泡抑素和激活素可能在卵巢内和垂体内具有重要功能，但在卵泡期不太可能发挥关键的内分泌作用。在人类和猴子身上使用重组和高度纯化形式的促卵泡激素进行的研究表明，这种激素是卵泡生长和发育的主要刺激物。对动物的研究可能导致对雌二醇在灵长类动物卵泡生长中局部作用的强调有误。虽然雌二醇可能对卵母细胞有一些重要的直接影响，但它似乎不是人类关键的促卵泡激素。
