Findlay J K
Prince Henry's Institute of Medical Research, Clayton, Vic., Australia.
Reprod Fertil Dev. 1994;6(2):127-39. doi: 10.1071/rd9940127.
The role of the gonadotrophins follicle-stimulating hormone (FSH) and luteinizing hormone and the putative local regulators, activin and follistatin, in the control of folliculogenesis is reviewed. An account of early work on the development and application of assays for FSH and inhibin is given, together with a summary of the data on the ovarian responsiveness to gonadotrophin and follicular atresia. Models for studying local regulation of granulosa cells in vitro are described and the data from these experiments reviewed. It is concluded that activin has a role in the development and maintenance of healthy oestrogenic follicles, preventing premature luteinization, whereas follistatin opposes these effects of activin and promotes luteinization or atresia.
本文综述了促性腺激素卵泡刺激素（FSH）和黄体生成素以及假定的局部调节因子激活素和卵泡抑素在卵泡发生控制中的作用。文中介绍了早期关于FSH和抑制素检测方法的开发与应用的工作，并总结了卵巢对促性腺激素反应性及卵泡闭锁的数据。描述了体外研究颗粒细胞局部调节的模型，并对这些实验的数据进行了综述。结论是，激活素在健康雌激素卵泡的发育和维持中起作用，防止过早黄体化，而卵泡抑素则对抗激活素的这些作用并促进黄体化或闭锁。
