Servin F
Département d'Anesthésie-Réanimation, Hôpital Bichat, Paris.
Ann Fr Anesth Reanim. 1994;13(4):477-9. doi: 10.1016/s0750-7658(05)80676-8.
No evidence of hepatoxicity has been demonstrated with propofol. Propofol can be used for anaesthesia in patients suffering from moderate cirrhosis of the liver. Liver blood flow is preserved. Propofol dosage must be titrated to each patient's needs. Data concerning the use of propofol in patients suffering from severe hepatic failure or cholestasis are lacking. Propofol dosage in chronic alcoholic patients without cirrhosis must be increased.
尚未有证据表明丙泊酚具有肝毒性。丙泊酚可用于中度肝硬化患者的麻醉。肝血流得以保留。丙泊酚剂量必须根据每个患者的需求进行滴定。目前缺乏关于丙泊酚在严重肝功能衰竭或胆汁淤积患者中使用的数据。无肝硬化的慢性酒精性患者的丙泊酚剂量必须增加。
